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Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in aqueous buffer (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Molecular Formula C65 H126 N10 O12 S
Sequence (one letter) CSKKKK
Modifications (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
PubChem identifier 71457280
InChiKey LJUIOEFZFQRWJG-GHYFRYPYSA-N
References for Pam2CSK4 References are publications that support the biological activity of the product
The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Parra-Izquierdo I et al (2021) Frontiers in immunology 12 : 729951 Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. Souza JAC et al (2020) Brazilian oral research 34 : e012 Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Kulsantiwong P et al (2017) Inflammation research : official journal of the European Histamine Research Society ... [et al.] 66 : 843-853 The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. Halliday A et al (2016) Parasites & vectors 9 : 96
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TLR2/6 activator. Induces potent NF-κB activation and cytokine production.