Pam2CSK4

(HB3086)

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Product overview

Name Pam2CSK4
Biological description

Synthetic lipopeptide which mimics bacterial lipoprotein. Pam2CSK4 is recognized by the TLR2/TLR6 heterodimer to induce NF-κB activation and cytokine production. Induces platelet activation in a TLR2/TLR6/NF-κB -dependent manner. Also acts as an effective immune adjuvant.

Alternative names Pam2CysSerLys4, Pam2
Purity >95%
Description

TLR2/6 activator. Induces potent NF-κB activation and cytokine production.

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in aqueous buffer (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 1271.83
Molecular Formula C65H126N10O12S
Sequence (one letter) CSKKKK
Modifications (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
CAS Number 868247-72-7
PubChem identifier 71457280
InChiKey LJUIOEFZFQRWJG-GHYFRYPYSA-N
Appearance White solid

References for Pam2CSK4

References are publications that support the biological activity of the product
  • The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions.

    Parra-Izquierdo I et al (2021) Frontiers in immunology 12 : 729951
  • Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice.

    Souza JAC et al (2020) Brazilian oral research 34 : e012
  • Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7.

    Kulsantiwong P et al (2017) Inflammation research : official journal of the European Histamine Research Society ... [et al.] 66 : 843-853
  • The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models.

    Halliday A et al (2016) Parasites & vectors 9 : 96

4 Item(s)