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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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Leupeptin hemisulfate (HB3958)
Description:Reversible trypsin-like and cysteine proteases inhibitor
Purity:>97%
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LIH383 (HB9242)
Description:Potent and selective ACKR3 (CXCR7) agonist. Potentiates opioid peptide activity.
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Linagliptin (HB4637)
Description:Highly potent, selective, competitive dipeptidyl-peptidase 4 inhibitor
Purity:>98%
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Loperamide hydrochloride (HB0385)
Description:Potent, selective µ-opioid receptor agonist
Purity:>99%
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