Novel, potent and highly selective atypical chemokine receptor ACKR3 (CXCR7) agonist. Competes directly with CXCL12-AF647 for ACKR3 binding at low nanomolar concentrations and is more potent in inducing beta-arrestin recruitment to ACKR3 (EC50 = 0.61 nM) than the CXCL12 and CXCL11 chemokine ligands (EC50 = 1.2 and 2.2 nM respectively). Restrains the negative regulatory function of ACKR3 on opioid peptides to potentiate their activity in rat brain.
Purity
>95%
Description
Potent and selective ACKR3 (CXCR7) agonist. Potentiates opioid peptide activity.
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
