DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
YM 298198 hydrochloride (HB0664)
Description:Potent, selective, non-competitive mGlu1 antagonist
Purity:>99%
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Yoda2 (KC289) (HB9134)
Description:Novel, selective Piezo1 channel activator. Improved efficacy, potency and solubility compared to Yoda1.
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Zacopride hydrochloride (HB1694)
Description:Potent 5-HT3 antagonist and 5-HT4 agonist. Also selective IK1 channel agonist.
Purity:>99%
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Zatebradine hydrochloride (HB1151)
Description:HCN channel blocker. Potent, selective bradycardic agent.
Purity:>95%
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ZD 7288 (HB1152)
Description:HCN channel blocker. Modulates sino-atrial node function.
Purity:>98%
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Zebularine (HB1378)
Description:DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.
Purity:>99%
