Product overview

Name Z-DEVD-FMK
Purity >95%
Description Irreversible, selective caspase 3 inhibitor
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Biological Data

Biological description Irreversible and selective caspase 3 inhibitor (IC50 = 0.13 µM). Cell permeable. Exhibits no activity at cathespin B and cathespin L. Displays neuroprotective properties and inhibits apoptosis.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (13.37mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Molecular Weight 668.67
Molecular Formula C30H41FN4O12
CAS Number 210344-95-9
PubChem identifier 16760394
SMILES [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1
InChiKey GBJVAVGBSGRRKN-JYEBCORGSA-N

References for Z-DEVD-FMK

References are publications that support the biological activity of the product
  • Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.

    Lee J et al (2010) ACS Chem Biol 5(2) : 233-43.
  • Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.

    Kugawa F et al (2000) Biol Pharm Bull 23(8) : 930-5.
  • Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

    Henshall DC et al (2000) J Neurochem 74(3) : 1215-23.
  • Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

    Brockstedt E et al (1998) J Biol Chem 273(43) : 28057-64.

4 Item(s)