Z-DEVD-FMK

Name: Z-DEVD-FMK
Brand: Hellobio
SKU: HB1282
Price: 299 USD
Availability: InStock

(HB1282)

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Technical documents: SDS Datasheet

Product overview

Name

Z-DEVD-FMK

Purity

>95%

Description

Irreversible, selective caspase 3 inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Biological Data

Biological description

Irreversible and selective caspase 3 inhibitor (IC₅₀ = 0.13 µM). Cell permeable. Exhibits no activity at cathespin B and cathespin L. Displays neuroprotective properties and inhibits apoptosis.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in DMSO (13.37mg/ml)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>95%

Chemical name

Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone

Molecular Weight

668.67

Molecular Formula

C₃₀H₄₁FN₄O₁₂

CAS Number

210344-95-9

PubChem identifier

16760394

SMILES

[H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

InChiKey

GBJVAVGBSGRRKN-JYEBCORGSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Z-DEVD-FMK

References are publications that support the biological activity of the product

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Lee J et al (2010) ACS Chem Biol 5(2) : 233-43.
Read more (PubMedID: 20017516)
Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.
Kugawa F et al (2000) Biol Pharm Bull 23(8) : 930-5.
Read more (PubMedID: 10963298)
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
Henshall DC et al (2000) J Neurochem 74(3) : 1215-23.
Read more (PubMedID: 10693954)
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.
Brockstedt E et al (1998) J Biol Chem 273(43) : 28057-64.
Read more (PubMedID: 9774422)

Irreversible, selective caspase 3 inhibitor

Order: HB1282
Pack	Price	Qty
1mg	$299
5mg	$1,211

Z-DEVD-FMK

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Z-DEVD-FMK

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.

Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.

Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

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Z-DEVD-FMK

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Z-DEVD-FMK

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.

Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.

Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area