Product overview

Name Z-DQMD-FMK
Description Cell permeable caspase 3 specific inhibitor
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Biological Data

Biological description Cell permeable caspase 3 specific inhibitor. Attenuates β-catenin degradation but does not affect β-catenin and GSK-3β phosphorylation

Solubility & Handling

Solubility overview Soluble in DMSO (13.71mg/ml)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Molecular Weight 685.72
Molecular Formula C29H40FN5O11S
PubChem identifier 644197
SMILES [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1
InChiKey QFITYVNVMNJELE-TUFLPTIASA-N

References for Z-DQMD-FMK

References are publications that support the biological activity of the product
  • Photodynamic therapy in combination with talaporfin sodium induces mitochondrial apoptotic cell death accompanied with necrosis in glioma cells.

    Miki Y et al (2013) Biol Pharm Bull 36(2) : 215-21.
  • Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat.

    Zhang H et al (2008) Neuroreport 19(8) : 821-4.

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