DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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Ziprasidone hydrochloride (HB1753)
Description:5-HT2A and D2 antagonist. Atypical antipsychotic.
Purity:>99%
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Z-Leu-Leu-Leu-B(OH)2 (MG-262) (HB4134)
Description:Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
Purity:>95%
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Z-Leu-Leu-Nva-CHO (HB4136)
Description:Potent, reversible and cell permeable proteasome inhibitor
Purity:>95%
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Z-Leu-Leu-Phe-CHO (HB4137)
Description:Reversible and cell permeable proteasome inhibitor
Purity:>95%
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ZM 447439 (HB1444)
Description:Potent, selective, ATP-competitive Aurora kinase B inhibitor
Purity:>99%
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Zoledronic acid (HB0674)
Description:Highly potent bisphosphonate, shows variety of biological actions
