Kinase
Protein kinases (phosphotransferases) are enzymes that catalyze phosphorylation. They phosphorylate specific amino acids using ATP as the source of phosphate. In this way, the biological activity of proteins is regulated; phosphorylation induces a conformational change from an inactive to an active form of the protein. Researchers can save up to 50% on kinase inhibitors and activators from Hello Bio - they are up to half the price of other suppliers.Â
View products: Akt / PKB | AMPK | Aurora kinase | BTK | CAM Kinase II | Casein kinase | CDK | c-Src | DYRK | ERK | GRK | GSK-3 | Hexokinase | JAK | MAPK | mTOR | Myosin light chain kinase (MLCK) | Non-selective | PKA | PKC | PKG | PI-3K | Protein-serine/threonine kinase | Protein-tyrosine kinase | RIP | ROCK | RSK| Sphingosine kinase | Syk |Raf | View Resources: Enzyme Inhibitors & Activators
SB 216763 (HB1272)
Description:Potent, selective cell permeable GSK-3 inhibitor. Maintains mESCs and promotes retinal stem cells proliferation.
Purity:>98%
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SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
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SP600125 (HB2234)
Description:Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
Purity:>98%
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SU 5402 (HB3133)
Description:Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Purity:>95%
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Thiazovivin (HB3240)
Description:Rock inhibitor. Improves hESCs survival and fibroblast reprogramming efficiency and iPSCs induction.
Purity:>97%
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Troglitazone (HB2559)
Description:Potent, selective PPARγ agonist. Inhibits hematopoietic cell line growth.
Purity:>97%
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ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts.
Purity:>99%
