Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. GSK 429286 (HB2290)

    Description:

    Selective ROCK inhibitor

    Purity:

    >97%

    Pack:
    10mg
    Price:
    $278
    Qty:
  2. GSK'872 (HB5933)

    Description:

    Potent, selective RIP3 inhibitor. Necroptosis inhibitor.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $139
    Free trial
    Qty:
    Pack:
    50mg
    Price:
    $584
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $91
    Qty:
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    Description:

    Potent, non-selective kinase inhibitor.Also improves dissociate hESCs survival and clonogenicity.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $147
    Qty:
    Pack:
    50mg
    Price:
    $622
    Qty:
  4. Description:

    Selective, reversible, cell-permeable ROCK inhibitor

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $237
    Qty:
  5. Pack:
    100mg
    Price:
    $90
    Qty:
  6. Helenalin (HB3927)

    Description:

    NF-κB inhibitor

    Purity:

    >97%

    Pack:
    500μg
    Price:
    $403
    Qty:
  7. Heliquinomycin (HB3928)

    Description:

    DNA helicase inhibitor

    Purity:

    >80%

    Pack:
    250μg
    Price:
    $357
    Qty:
    Pack:
    500μg
    Price:
    $595
    Qty:
  8. Pack:
    100g
    Price:
    $127
    Qty:
    Pack:
    250g
    Price:
    $253
    Qty:
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