Potent and selective JAK2 tyrosine kinase inhibitor, inhibits autophosphorylation of JAK2. Shows apoptotic actions
Solubility & Handling
Solubility overview
Soluble in DMSO (10mM, gentle warming)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT.
Reindl KM et al (2011) Am J Physiol Regul Integr Comp Physiol 301(1) : R236-43.
Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.
Samanta AK et al (2009) Oncogene 28(14) : 1669-81.
Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].
Sandberg EM et al (2005) J Med Chem 48(7) : 2526-33.
![1,2,3,4,5,6-Hexabromocyclohexane [1837-91-8] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1428.png "1,2,3,4,5,6-Hexabromocyclohexane [1837-91-8]")
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