Hedgehog signaling

TRPV1 channel agonist

TRPV1 channel antagonist

ACE and LTA₄ hydrolase inhibitor

Cisplatin analog. Blocks DNA replication and transcription.

Competitive, selective group 1 mGlu antagonist

NO scavenger

K_2P2.1 (TREK-1) modulator. Selectively and irreversibly activates TREK-1^CG* but not wild-type K_2P2.1 (TREK-1)

Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.

Selective mGlu₅ positive allosteric modulator

β-lactam antibiotic. Increases EAAT2 activity.