Organoids
Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.
- Description:
Water soluble Toll-like receptor 7 (TLR7) agonist. Stimulates cytokine production.
Purity:>98%
ITD 1 (HB3446)
Description:Selective TGF-β signaling inhibitor. Induces cardiomyocyte differentiation in ESCs.
Purity:>98%
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LDN193189 hydrochloride (LDN) (HB5624)
Description:Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.
Purity:>98%
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Pam2CSK4 (HB3086)
Description:TLR2/6 activator. Induces potent NF-κB activation and cytokine production.
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Pam3CSK4 (HB3428)
Description:TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.
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PD 173074 (HB3584)
Description:FGFR1/ FGFR3 inhibitor. Inhibits oligodendrocyte progenitor proliferation and differentiation.
Purity:>98%
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Pexidartinib (PLX3397) (HB8991)
Description:Potent CSF-1R inhibitor. Widely used microglia-depletion agent.
Purity:>98%
