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PD 173074

(HB3584)
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Product overview

Name PD 173074
Purity >98%
Description FGFR1/ FGFR3 inhibitor. Inhibits oligodendrocyte progenitor proliferation and differentiation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description FGFR1/ FGFR3 inhibitor (IC50 values are 22 and 5 nM respectively). Inhibits angiogenesis. Also inhibits oligodendrocyte progenitor proliferation and differentiation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[2-[[4-(Diethylamino)butyl]amino] -6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-y l]-N'-(1,1-dimethylethyl)urea
Molecular Weight 523.67
Chemical structure PD 173074 | [219580-11-7] Chemical Structure
Molecular Formula C28H41N7O3
CAS Number 219580-11-7
PubChem identifier 1401
SMILES O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3
InChiKey DXCUKNQANPLTEJ-UHFFFAOYSA-N

References for PD 173074

References are publications that support the biological activity of the product

  • The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1.

    Nguyen et al (2013) Br J Cancer 109(8) : 2248-58
    Read more (PubMedID: 24045665)

  • 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carryi

    Miyake et al (2010) J Pharmacol Exp Ther 332(3) : 795-802
    Read more (PubMedID: 19955487)

  • The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects.

    Skaper et al (2000) J Neurochem 75(4) : 1520-7
    Read more (PubMedID: 10987832)

3 Item(s)

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Order: HB3584
Pack PriceQty
10mg
$215
50mg
$835
FGFR1/ FGFR3 inhibitor. Inhibits oligodendrocyte progenitor proliferation and differentiation.
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