Organoids
Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.
Strontium chloride (HB3424)
Description:Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.
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SU 5402 (HB3133)
Description:Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Purity:>95%
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T3 (triiodothyronine) (HB7470)
Description:Thyroid hormone. Frequently used in various stem cell protocols.
Purity:>98%
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Venlafaxine hydrochloride (HB1743)
Description:Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%
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WHI-P 154 (HB1431)
Description:Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.
Purity:>99%
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Wnt-C59 (HB3155)
Description:Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.
Purity:>99%
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XAV 939 (HB0660)
Description:Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
Purity:>98%
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ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Purity:>99%
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Zebularine (HB1378)
Description:DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.
Purity:>99%
