DREADDs
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
Quetiapine hemifumarate (HB1803)
Description:5-HT2 and D2 antagonist. Atypical antipsychotic.
Purity:>99%
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SCH 23390 hydrochloride (HB1643)
Description:Potent, selective D1-like receptor antagonist
Purity:>98%
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SKF 38393 hydrochloride (HB6111)
Description:Prototypic, selective D1-like receptor partial agonist
Purity:>98%
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SKF 38393 hydrobromide (HB1840)
Description:Prototypic, selective D1-like receptor partial agonist
Purity:>98%
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SKF 83566 hydrobromide (HB1863)
Description:Potent, selective D1-like receptor antagonist
Purity:>98%
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Spiperone hydrochloride (HB1656)
Description:Selective D2-like receptor antagonist. 5-HT2A antagonist.
Purity:>98%
