Potent, selective D1-like receptor antagonist (Ki values are 0.3 and 0.4 nM at D1 and D5 receptors respectively). Also inhibits DAT (IC50 = 5.7 µM) and acts as a selective adenylyl cylase 2 (AC2) inhibitor. Centrally active following systemic administration.
Solubility & Handling
Storage instructions
room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.
Conley JM et al (2013) J Pharmacol Exp Ther 347(2) : 276-87.
![SKF 83566 hydrobromide [108179-91-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1863.png "SKF 83566 hydrobromide [108179-91-5]")
Understanding purity and quality - a guide for life scientists
