Product overview

Name SKF 83566 hydrobromide
Alternative names SKF-83566
Purity >98%
Description Potent, selective D1-like receptor antagonist
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Biological Data

Biological description Potent, selective D1-like receptor antagonist (Ki values are 0.3 and 0.4 nM at D1 and D5 receptors respectively). Also inhibits DAT (IC50 = 5.7 µM) and acts as a selective adenylyl cylase 2 (AC2) inhibitor. Centrally active following systemic administration.

Solubility & Handling

Storage instructions room temperature (desiccate)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
Molecular Weight 413.15
Chemical structure SKF 83566 hydrobromide  [108179-91-5] Chemical Structure
Molecular Formula C17H18BrNO.HBr
CAS Number 108179-91-5
PubChem identifier 23581817
SMILES Br.CN1CCC2=CC(Br)=C(O)C=C2C(C1)C1=CC=CC=C1
InChiKey SDQJYYGODYRPBR-UHFFFAOYSA-N

References for SKF 83566 hydrobromide

References are publications that support the biological activity of the product
  • Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

    Conley JM et al (2013) J Pharmacol Exp Ther 347(2) : 276-87.
  • SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter.

    Stouffer MA et al (2011) J Neurochem 118(5) : 714-20.
  • Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.

    Fritts ME et al (1998) Pharmacol Biochem Behav 60(3) : 639-44.
  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.

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