SKF 81297 hydrobromide

(HB1858)
Technical documents: SDS Datasheet

Product overview

Name SKF 81297 hydrobromide
Description D1-like receptor agonist
Purity >98%
Customer comments

SKF81297 hydrobromide is an excellent quality for a fair price. The product had an excellent quality and worked perfectly fine in our experiments. In addition, Hello Bio was the cheapest vendor we could find.Verified customer, MedUni Wien

Great Product. Compound (SKF 81297 hydrobromide) dissolves into solution easily and produces consistent results. Verified customer, Florida Atlantic University

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Biological Data

Biological description D1-like receptor agonist (Ki values are 2.2 and >1000 nM at D1 and D2 receptors respectively). Shows ~500 times greater affinity for D1 over D2. Stimulates motor behaviour. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Molecular Weight 370.67
Chemical structure SKF 81297 hydrobromide  [67287-39-2] Chemical Structure
Molecular Formula C16H16ClNO2.HBr
CAS Number 67287-39-2
PubChem identifier 11957706
SMILES Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1
InChiKey RMIJGBMRNYUZRG-UHFFFAOYSA-N

References for SKF 81297 hydrobromide

References are publications that support the biological activity of the product
  • Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6

    Yamamoto N et al (2008) Neuroscience 154(3) : 1088-99.
  • Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.

    Matell MS et al (2006) Behav Processes 71(2-3) : 241-9.
  • Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

    Cai JX et al (1997) J Pharmacol Exp Ther 283(1) : 183-9.
  • The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.

    Vermeulen RJ et al (1993) Eur J Pharmacol 235(1) : 143-7.

4 Item(s)

Publications
These publications cite the use of SKF 81297 hydrobromide purchased from Hello Bio:
  • The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors

    Nesbit MO et al (2022) Neuropharmacology 207 : 108967
    PubMedID: 35077763
  • Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking

    Alvarez et al (2022) Biorxiv : https://doi.org/10.1101/2022.05.26.493614
  • Loss of LrrK2 Function Potentiates Dopamine Signaling in the Striatum to Promote Compulsive Alcohol Use

    Matsui et al et al (2020) Cell Reports 49
  • A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

    Bocarsly ME et al (2019) Cell Rep 29(5) : 1147-1163.e5
    PubMedID: 31665630

4 Item(s)