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SKF 81297 hydrobromide

Name: SKF 81297 hydrobromide
Brand: Hello Bio
SKU: HB1858
Price: 164 USD
Availability: InStock
Rating: 100 (4 reviews)

(HB1858)

Publications (4)

Technical documents: SDS CoA Datasheet

Product overview

Name

SKF 81297 hydrobromide

Purity

>98%

Customer comments

SKF81297 hydrobromide is an excellent quality for a fair price. The product had an excellent quality and worked perfectly fine in our experiments. In addition, Hello Bio was the cheapest vendor we could find.Verified customer, MedUni Wien

Great Product. Compound (SKF 81297 hydrobromide) dissolves into solution easily and produces consistent results. Verified customer, Florida Atlantic University

Description

D₁-like receptor agonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (4) Publications (4) References (4) Frequently bought together

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Biological Data

Biological description

D₁-like receptor agonist (K_i values are 2.2 and >1000 nM at D₁ and D₂ receptors respectively). Shows ~500 times greater affinity for D₁ over D₂. Stimulates motor behaviour. Active in vivo.

Solubility & Handling

Storage instructions

+4°C (desiccate)

Solubility overview

Soluble in DMSO (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide

Molecular Weight

370.67

Chemical structure

Molecular Formula

C₁₆H₁₆ClNO₂.HBr

CAS Number

67287-39-2

PubChem identifier

11957706

SMILES

Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1

InChiKey

RMIJGBMRNYUZRG-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for SKF 81297 hydrobromide

References are publications that support the biological activity of the product

Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6
Yamamoto N et al (2008) Neuroscience 154(3) : 1088-99.
Read more (PubMedID: 18495353)
Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.
Matell MS et al (2006) Behav Processes 71(2-3) : 241-9.
Read more (PubMedID: 16246504)
Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.
Cai JX et al (1997) J Pharmacol Exp Ther 283(1) : 183-9.
Read more (PubMedID: 9336323)
The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.
Vermeulen RJ et al (1993) Eur J Pharmacol 235(1) : 143-7.
Read more (PubMedID: 8100193)

Publications

Submit Yours Now

These publications cite the use of SKF 81297 hydrobromide purchased from Hello Bio:

The selective dopamine D₁ receptor agonist SKF81297 modulates NMDA receptor currents independently of D₁ receptors
Nesbit MO et al (2022) Neuropharmacology 207 : 108967
PubMedID: 35077763
Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking
Alvarez et al (2022) Biorxiv : https://doi.org/10.1101/2022.05.26.493614
Loss of LrrK2 Function Potentiates Dopamine Signaling in the Striatum to Promote Compulsive Alcohol Use
Matsui et al et al (2020) Cell Reports 49
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors
Bocarsly ME et al (2019) Cell Rep 29(5) : 1147-1163.e5
PubMedID: 31665630

D₁-like receptor agonist

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Order: HB1858
Pack	Price	Qty
10mg	$164
25mg	$349

SKF 81297 hydrobromide

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for SKF 81297 hydrobromide

Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6

Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.

Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.

The selective dopamine D₁ receptor agonist SKF81297 modulates NMDA receptor currents independently of D₁ receptors

Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking

Loss of LrrK2 Function Potentiates Dopamine Signaling in the Striatum to Promote Compulsive Alcohol Use

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

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Tell us about your publication!

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New Products in this Area

SKF 81297 hydrobromide

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for SKF 81297 hydrobromide

Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6

Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.

Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.

The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors

Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking

Loss of LrrK2 Function Potentiates Dopamine Signaling in the Striatum to Promote Compulsive Alcohol Use

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

About you

Tell us about your publication!

Captcha

About you

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The selective dopamine D₁ receptor agonist SKF81297 modulates NMDA receptor currents independently of D₁ receptors