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Biological Data Biological description Potent and selective D1 -like receptor antagonist (Ki values are 0.2, 0.3, ~800, ~1100, ~3000 nM at D1 , D5 , D3 , D2 and D4 respectively). Also acts as an agonist at 5-HT1C and 5-HT2C (Ki values are 6.3 and 9.3 respectively). Shows anxiolytic and anticonvulsant effects. Active in vivo .
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM), DMSO (100mM), ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (R )-(+)-7-Chloro-8-hydroxy-3-methyl -1-phenyl-2,3,4,5-tetrahydro-1H -3-benzazepine hydrochloride
Chemical structure
Molecular Formula C17 H18 ClNO.HCl
PubChem identifier 11957535
SMILES ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl
InChiKey OYCAEWMSOPMASE-XFULWGLBSA-N
References for SCH 23390 hydrochloride References are publications that support the biological activity of the product
The 'selective' dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Millan MJ et al (2001) Psychopharmacology (Berl) 156(1) : 58-62. SCH 23390: the first selective dopamine D1-like receptor antagonist. Bourne JA (2001) CNS Drug Rev 7(4) : 399-414. Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum. Zhang X et al (1989) Jpn J Pharmacol 50(3) : 333-45.
Publications
These publications cite the use of SCH 23390 hydrochloride purchased from Hello Bio:
The dopamine neuron synaptic map in the striatum. Chuhma N et al (2023) Cell reports 42 : 112204 The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors Nesbit MO et al (2022) Neuropharmacology 207 : 108967 Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors Toval A et al (2021) Mol Neurobiol 58(4) : 1782-1791 Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons Chuhma et al (2018) eLIFE 7:e39786 : DOI: 10.7554/eLife.39786
Potent, selective D1 -like receptor antagonist
![SCH 23390 hydrochloride [125941-87-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1643.png "SCH 23390 hydrochloride [125941-87-9]")
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