SCH 23390 hydrochloride

Technical documents: SDS CoA Datasheet

Product overview

Name SCH 23390 hydrochloride
Alternative names (R)-(+)-SCH 23390 hydrochloride
Purity >98%
Description Potent, selective D1-like receptor antagonist
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Biological Data

Biological description Potent and selective D1-like receptor antagonist (Ki values are 0.2, 0.3, ~800, ~1100, ~3000 nM at D1, D5, D3, D2 and D4 respectively). Also acts as an agonist at 5-HT1C and 5-HT2C (Ki values are 6.3 and 9.3 respectively). Shows anxiolytic and anticonvulsant effects. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM), DMSO (100mM), ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (R)-(+)-7-Chloro-8-hydroxy-3-methyl -1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
Molecular Weight 324.24
Chemical structure SCH 23390 hydrochloride  [125941-87-9] Chemical Structure
Molecular Formula C17H18ClNO.HCl
CAS Number 125941-87-9
PubChem identifier 11957535
SMILES ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl

References for SCH 23390 hydrochloride

References are publications that support the biological activity of the product
  • The 'selective' dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors.

    Millan MJ et al (2001) Psychopharmacology (Berl) 156(1) : 58-62.
  • SCH 23390: the first selective dopamine D1-like receptor antagonist.

    Bourne JA (2001) CNS Drug Rev 7(4) : 399-414.
  • Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.

    Zhang X et al (1989) Jpn J Pharmacol 50(3) : 333-45.

3 Item(s)

These publications cite the use of SCH 23390 hydrochloride purchased from Hello Bio:
  • The dopamine neuron synaptic map in the striatum.

    Chuhma N et al (2023) Cell reports 42 : 112204
    PubMedID: 36867530
  • The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors

    Nesbit MO et al (2022) Neuropharmacology 207 : 108967
    PubMedID: 35077763
  • Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors

    Toval A et al (2021) Mol Neurobiol 58(4) : 1782-1791
    PubMedID: 33394335
  • Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Chuhma et al (2018) eLIFE 7:e39786 : DOI: 10.7554/eLife.39786

4 Item(s)