Product overview

Name SKF 38393 hydrochloride
Description Prototypic, selective D1-like receptor partial agonist
Alternative names SKF38393
Purity >98%
Write Your Own Review
You're reviewing:SKF 38393 hydrochloride
Rate this item:

Biological Data

Biological description

Prototypic, selective D1-like dopamine receptor partial agonist (Ki values are 1 and ~ 0.5 nM at D1-like receptors (D1 and D5) and ~ 150, ~ 5000 and ~ 1000 nM at D2-like receptors (D2, D3 and D4) respectively). Hydrochloride salt.

SKF 38393 facilitates long term potentiation (LTP) via D1 and D5 activation and has also been shown to presynaptically stimulate glutamate release in the hippocampus.

Additionally activates the HPA axis to increase ACTH and corticosterone levels.

Shows proconvulsant and anorexic effects.

Blood brain barrier permeable.

Active in vivo.

SKF 38393 hydrobromide also available.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (50 mM, warming) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Chemical name (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride
Molecular Weight 291.77
Chemical structure SKF 38393 [62717-42-2] Chemical Structure
Molecular Formula C16H17NO2.HCl
CAS Number 62717-42-4
PubChem identifier 147514
Source Synthetic
InChi InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
MDL number MFCD00069248
Appearance White Solid

References for SKF 38393 hydrochloride

References are publications that support the biological activity of the product
  • D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.

    Stramiello and Wagner (2008) Neuropharmacology 55(5) : 871-7
  • Dopamine receptor pharmacology.

    Seeman and Van Tol (1994) Trends Pharmacol Sci. 15(5) : 264-70
  • Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.

    Katz JL et al (1992) Psychopharmacology (Berl) 107(2-3) : 217-20.
  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.
  • The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour.

    Cooper SJ et al (1990) Psychopharmacology (Berl) : 100(2)

5 Item(s)