SKF 38393 hydrochloride
(HB6111)
Product overview
| Name | SKF 38393 hydrochloride |
| Description | Prototypic, selective D1-like receptor partial agonist |
| Alternative names | SKF38393 |
| Purity | >98% |
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Biological Data
| Biological description | Prototypic, selective D1-like dopamine receptor partial agonist (Ki values are 1 and ~ 0.5 nM at D1-like receptors (D1 and D5) and ~ 150, ~ 5000 and ~ 1000 nM at D2-like receptors (D2, D3 and D4) respectively). Hydrochloride salt.
Additionally activates the HPA axis to increase ACTH and corticosterone levels. Shows proconvulsant and anorexic effects. Blood brain barrier permeable. Active in vivo.
|
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (50 mM, warming) and in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride |
| Molecular Weight | 291.77 |
| Chemical structure | ![SKF 38393 [62717-42-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb6111.png "SKF 38393 [62717-42-2]") |
| Molecular Formula | C16H17NO2.HCl |
| CAS Number | 62717-42-4 |
| PubChem identifier | 147514 |
| SMILES | C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl |
| Source | Synthetic |
| InChi | InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H |
| InChiKey | YEWHJCLOUYPAOH-UHFFFAOYSA-N |
| MDL number | MFCD00069248 |
| Appearance | White Solid |
References for SKF 38393 hydrochloride
References are publications that support the biological activity of the product
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D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
Stramiello and Wagner (2008) Neuropharmacology 55(5) : 871-7 -
Dopamine receptor pharmacology.
Seeman and Van Tol (1994) Trends Pharmacol Sci. 15(5) : 264-70 -
Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.
Katz JL et al (1992) Psychopharmacology (Berl) 107(2-3) : 217-20. -
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Sunahara RK et al (1991) Nature 350(6319) : 614-9. -
The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour.
Cooper SJ et al (1990) Psychopharmacology (Berl) : 100(2)
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