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Biological Data Biological description Prototypic, selective D1 -like dopamine receptor partial agonist (Ki values are 1 and ~ 0.5 nM at D1 -like receptors (D1 and D5 ) and ~ 150, ~ 5000 and ~ 1000 nM at D2 -like receptors (D2 , D3 and D4 ) respectively).
1 and D5 activation and has also been shown to presynaptically stimulate glutamate release in the hippocampus.
Additionally activates the HPA axis to increase ACTH and corticosterone levels.
Shows proconvulsant and anorexic effects.
Blood brain barrier permeable.
Active in vivo.
SKF 38393 hydrochloride also available.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (25 mM, warming) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H )-3-benzazepine-7,8-diol hydrobromide
Chemical structure
Molecular Formula C16 H17 NO2 .HBr
PubChem identifier 12928470
SMILES C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Br
InChi InChI=1S/C16H17NO2.BrH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
InChiKey INNWVRBZMBCEJI-UHFFFAOYSA-N
References for SKF 38393 hydrobromide References are publications that support the biological activity of the product
D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Stramiello and Wagner (2008) Neuropharmacology 55(5) : 871-7 Dopamine receptor pharmacology. Seeman and Van Tol (1994) Trends Pharmacol Sci. 15(5) : 264-70 Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine. Katz JL et al (1992) Psychopharmacology (Berl) 107(2-3) : 217-20. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Sunahara RK et al (1991) Nature 350(6319) : 614-9. The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour. Cooper SJ et al (1990) Psychopharmacology (Berl) : 100(2)
Publications
These publications cite the use of SKF 38393 hydrobromide purchased from Hello Bio:
The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors Nesbit MO et al (2022) Neuropharmacology 207 : 108967
Prototypic, selective D1 -like receptor partial agonist
![SKF 38393 hydrobromide [20012-10-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1840.png "SKF 38393 hydrobromide [20012-10-6]")
Understanding purity and quality - a guide for life scientists
