Antagonists & inhibitors
An antagonist is a drug or chemical that reduces the effect of an agonist. Competitive antagonists bind to the same site on a receptor as the agonist but do not activate it - thereby blocking the action of the agonist. Non-competitive antagonists block the action of the agonist by binding to a different site on the receptor (an allosteric or non-agonist site). A reversible antagonist binds non-covalently and can be washed out. An irreversible antagonist binds covalently and cannot be displaced by either competing ligands or washing. Inhibitors are drugs that can bind to a protein, such as an enzyme and decrease its activity. Researchers can save up to 50% on competitive antagonists, non-competitive antagonists, reversible and irreversible antagonists, and inhibitors from Hello Bio - they are up to half the price of other suppliers.
Recombinant human beta-NGF protein (HB9303)
Description:Neurotrophic factor related to BDNF, NT-3 and NT-4
Recombinant human GDNF protein (HB5735)
Description:Neurotrophin which enhances differentiation and survival of dopaminergic neurons
Recombinant human NT-3 protein (HB8373)
Description:Neurotrophin involved in neuron development, survival and differentiation
Rosiglitazone (HB2556)
Description:Potent and selective PPARγ agonist. Promotes adipocyte differentiation and enhances NPC proliferation.
Purity:>99%
SAG (HB3107)
Description:Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
Purity:>98%
SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
Sodium butyrate (HB1399)
Description:HDAC inhibitor. Directs mESC differentiation into hepatocytes.
SP600125 (HB2234)
Description:Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
Purity:>98%
Stauprimide (HB3011)
Description:NME2 nuclear translocation inhibitor. Primes ESCs for differentiation.
Purity:>98%