Recombinant human CNTF protein

Technical documents: CoA Datasheet

Product overview

Name Recombinant human CNTF protein
Biological description

The CNTF neural factor appears to act only on the nervous system and is thought to promote neurotransmitter synthesis and neurite outgrowth in some neuronal populations.

It is potent survival factor for neurons and oligodendrocytes.

CNTF is often used when differentiating hPSC-derived neural progenitor cells into astrocytes.

Alternative names Recombinant Human Ciliary Neurotrophic Factor, HCNTF, CNTF, Ciliary Neurotrophic Factor.
Purity >98%
Description Potent neural factor
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Biological Data

Application notes ED50 = <2 ng/ml (determined by dose-dependent stimulation of TF-1 cells), corresponding to a specific activity of 500,000IU/mg.

Solubility & Handling

Storage instructions -20°C and avoid freeze thaw cycles
Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Molecular Weight 22.7
Source E. Coli.
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing 5mM sodium Phosphate buffer (pH 7.5) and 5mM sodium chloride

References for Recombinant human CNTF protein

References are publications that support the biological activity of the product
  • Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

    Pasquin S et al (2015) Cytokine Growth Factor Rev 26(5) : 507-15
  • Ciliary neurotrophic factor (CNTF) promotes skeletal muscle progenitor cell (MPC) viability via the phosphatidylinositol 3-kinase-Akt pathway

    Hiatt K et al (2014) J Tissue Eng Regen Med 8(12) : 963-8
  • The ciliary neurotrophic factor and its receptor, CNTFR alpha

    Sleeman MW et al (2000) Pharm Acta Helv 74(2-3) : 265-72

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