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Biological Data Application notes ED50 = <2 ng/ml (determined by dose-dependent stimulation of TF-1 cells), corresponding to a specific activity of 500,000IU/mg.
Solubility & Handling Storage instructions -20°C and avoid freeze thaw cycles
Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing 5mM sodium Phosphate buffer (pH 7.5) and 5mM sodium chloride
References for Recombinant human CNTF protein References are publications that support the biological activity of the product
Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies Pasquin S et al (2015) Cytokine Growth Factor Rev 26(5) : 507-15 Ciliary neurotrophic factor (CNTF) promotes skeletal muscle progenitor cell (MPC) viability via the phosphatidylinositol 3-kinase-Akt pathway Hiatt K et al (2014) J Tissue Eng Regen Med 8(12) : 963-8 The ciliary neurotrophic factor and its receptor, CNTFR alpha Sleeman MW et al (2000) Pharm Acta Helv 74(2-3) : 265-72
Understanding purity and quality - a guide for life scientists
