Agonists & activators
An agonist or activator, is a drug or chemical that binds to and activates a protein, such as receptor or enzyme. Full agonists have high efficacy, eliciting a full response whilst occupying a small proportion of receptors. Partial agonists have a lower efficacy and cannot produce a maximal response, even if occupying a high proportion of receptors. Inverse agonists can bind to the same receptor binding-site as an agonist, but elicit an opposite effect. Researchers can save up to 50% on activators, agonists, partial agonists and inverse agonists from Hello Bio - they are up to half the price of other suppliers.
Recombinant human beta-NGF protein (HB9303)
Description:Neurotrophic factor related to BDNF, NT-3 and NT-4
Recombinant human GDNF protein (HB5735)
Description:Neurotrophin which enhances differentiation and survival of dopaminergic neurons
Recombinant human NT-3 protein (HB8373)
Description:Neurotrophin involved in neuron development, survival and differentiation
Rosiglitazone (HB2556)
Description:Potent and selective PPARγ agonist. Promotes adipocyte differentiation and enhances NPC proliferation.
Purity:>99%
SAG (HB3107)
Description:Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
Purity:>98%
SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
Sodium butyrate (HB1399)
Description:HDAC inhibitor. Directs mESC differentiation into hepatocytes.
SP600125 (HB2234)
Description:Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
Purity:>98%
Stauprimide (HB3011)
Description:NME2 nuclear translocation inhibitor. Primes ESCs for differentiation.
Purity:>98%