Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Alprenolol hydrochloride (HB1734)
Description:Non-selective β-adrenoceptor antagonist. Also a 5-HT1A receptor antagonist.
Purity:>99%
Alsterpaullone (HB3754)
Description:Potent CDK1 inhibitor. Also shows activity at GSK-3β
Purity:>98%
Altenusin (HB3755)
Description:Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor.
Purity:>97%
AM251 (HB2776)
Description:Potent, selective CB1 receptor antagonist / inverse agonist
Purity:>98%
AM281 (HB2312)
Description:Potent, selective CB1 receptor antagonist / inverse agonist
Purity:>98%
AM 404 (HB1174)
Description:Selective, competitive carrier-mediated anandamide transport inhibitor
Purity:>98%
Amantadine hydrochloride (HB0109)
Description:Non-competitive NMDA receptor antagonist
Purity:>98%
Amastatin hydrochloride (HB3757)
Description:Competitive aminopeptidase (AP) inhibitor
Purity:>98%