Product overview
| Name | AM281 |
| Description | Potent, selective CB1 receptor antagonist / inverse agonist |
| Purity | >98% |
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Biological Data
| Biological description | AM 281 is a potent, selective CB1 receptor antagonist / inverse agonist which is selective for CB1 over CB2 receptors (Ki values are 12 nM and 4200 nM respectively). AM 281 modulates locomotor activity and shows neuroprotective actions in septic shock. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in DMSO (50 mM with heating) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-(2,4-Dichlorophenyl)-5-(4-iodophe nyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carbox amide |
| Molecular Weight | 557.22 |
| Chemical structure |  |
| Molecular Formula | C21H19Cl2IN4O2 |
| CAS Number | 202463-68-1 |
| PubChem identifier | 4302962 |
| SMILES | CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I |
| Source | Synthetic |
| InChi | InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29) |
| InChiKey | AJFFBPZYXRNAIC-UHFFFAOYSA-N |
| MDL number | MFCD01861180 |
| Appearance | White solid |
References for AM281
References are publications that support the biological activity of the product
-
Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats.
Kadoi et al (2005) Crit Care Med 33(11) : 2629-36 -
Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.
Lan et al (1999) AAPS PharmSci. 1(2) : E4 -
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.
Gifford et al (1997) Neurosci Lett. 238(1-2) : 84-6
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