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Biological Data

Biological description AM 281 is a potent, selective CB1 receptor antagonist / inverse agonist which is selective for CB1 over CB2 receptors (Ki values are 12 nM and 4200 nM respectively). AM 281 modulates locomotor activity and shows neuroprotective actions in septic shock.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (50 mM with heating)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 1-(2,4-Dichlorophenyl)-5-(4-iodophe nyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carbox amide
Molecular Weight 557.22
Chemical structure AM 281 Chemical Structure
Molecular Formula C21H19Cl2IN4O2
CAS Number 202463-68-1
PubChem identifier 4302962
SMILES CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
Source Synthetic
InChi InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
InChiKey AJFFBPZYXRNAIC-UHFFFAOYSA-N
MDL number MFCD01861180
Appearance White solid

References for AM281

References are publications that support the biological activity of the product
  • Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats.

    Kadoi et al (2005) Crit Care Med 33(11) : 2629-36
  • Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.

    Lan et al (1999) AAPS PharmSci. 1(2) : E4
  • Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.

    Gifford et al (1997) Neurosci Lett. 238(1-2) : 84-6