Slow, tight binding and competitive aminopeptidase (AP) inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A (AP-A), aminopeptidase N (AP-N), tyrosine aminopeptidase, but not of aminopeptidase B (AP-B). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III (Ang III) from Ang II through AP-A, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase (MIP). Weak inhibitor of simian immunodeficiency virus protease (SIV-PR).
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in aqueous buffers, and in ethanol
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![Amastatin hydrochloride [100938-10-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3757.png "Amastatin hydrochloride [100938-10-1]")
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