Product overview

Name Amantadine hydrochloride
Purity >98%
Description Non-competitive NMDA receptor antagonist
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Biological Data

Biological description Non-competitive NMDA receptor antagonist (IC50 = approx 35 µM). May also block serotonin uptake. Shows antiviral effects in vivo. Acts as a dopaminergic agent with anti-parkinsonian effects; suppresses L-DOPA-induced dyskinesia. Induces D2 and D3 receptor up-regulation. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name Adamantan-1-amine hydrochloride
Molecular Weight 187.71
Chemical structure Amantadine  [665-66-7] Chemical Structure
Molecular Formula C10H17N.HCl
CAS Number 665-66-7
PubChem identifier 64150
InChi InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
MDL number MFCD00074723

References for Amantadine hydrochloride

References are publications that support the biological activity of the product
  • Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.

    Jing et al (2008) Proc Natl Acad Sci U S A 105(31) : 10967-72
  • Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.

    Blanpied et al (2005) J Neurosci 25(13) : 3312-22
  • Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.

    Rogoz et al (2003) J Physiol Pharmacol. 54(2) : 257-70

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