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Biological Data
| Biological description | Non-competitive NMDA receptor antagonist (IC50 = approx 35 µM). May also block serotonin uptake. Shows antiviral effects in vivo. Acts as a dopaminergic agent with anti-parkinsonian effects; suppresses L-DOPA-induced dyskinesia. Induces D2 and D3 receptor up-regulation. Blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Adamantan-1-amine hydrochloride |
| Chemical structure | ![Amantadine [665-66-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Amantadine [665-66-7]") |
| Molecular Formula | C10H17N.HCl |
| SMILES | C1C2CC3CC1CC(C2)(C3)N.Cl |
| InChi | InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H |
| InChiKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
References for Amantadine hydrochloride
References are publications that support the biological activity of the product
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Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.
Jing et al (2008) Proc Natl Acad Sci U S A 105(31) : 10967-72 -
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.
Blanpied et al (2005) J Neurosci 25(13) : 3312-22 -
Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.
Rogoz et al (2003) J Physiol Pharmacol. 54(2) : 257-70
Non-competitive NMDA receptor antagonist
![Amantadine [665-66-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0109.png "Amantadine [665-66-7]")
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