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Amantadine hydrochloride

(HB0109)
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Product overview

Name Amantadine hydrochloride
Purity >98%
Description Non-competitive NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (3) Frequently bought together
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Biological Data

Biological description Non-competitive NMDA receptor antagonist (IC50 = approx 35 µM). May also block serotonin uptake. Shows antiviral effects in vivo. Acts as a dopaminergic agent with anti-parkinsonian effects; suppresses L-DOPA-induced dyskinesia. Induces D2 and D3 receptor up-regulation. Blood-brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in water (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name Adamantan-1-amine hydrochloride
Molecular Weight 187.71
Chemical structure Amantadine [665-66-7] Chemical Structure
Molecular Formula C10H17N.HCl
CAS Number 665-66-7
PubChem identifier 64150
SMILES C1C2CC3CC1CC(C2)(C3)N.Cl
InChi InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
InChiKey WOLHOYHSEKDWQH-UHFFFAOYSA-N
MDL number MFCD00074723

References for Amantadine hydrochloride

References are publications that support the biological activity of the product

  • Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.

    Jing et al (2008) Proc Natl Acad Sci U S A 105(31) : 10967-72
    Read more (PubMedID: 18669647)

  • Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.

    Blanpied et al (2005) J Neurosci 25(13) : 3312-22
    Read more (PubMedID: 15800186)

  • Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.

    Rogoz et al (2003) J Physiol Pharmacol. 54(2) : 257-70
    Read more (PubMedID: 12832726)

3 Item(s)

Grouped product items
Order: HB0109
Pack PriceQty
1g
$22
5g
$38
Non-competitive NMDA receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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