α-Bungarotoxin

Name: α-Bungarotoxin
Brand: Hello Bio
SKU: HB2038
Price: 206 USD
Availability: InStock

(HB2038)

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Technical documents: SDS CoA Datasheet

Product overview

Name

α-Bungarotoxin

Alternative names

α-BTX, α-Bgtx, α-BuTX, BGT

Purity

>99%

Description

α7 subtype selective nAChR antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Biological Data

Biological description

Irreversible, high affinity nicotinic acethylcholine receptor (nAChR) antagonist. Neurotoxin. Shows subtype selectivity for α7 over α3β4 receptors.

Shows activity at the heteromeric muscle receptors (αβγδ or αβδε subunits) and neuronal subtypes (α7, α8, α9 subunits, (IC₅₀ values are 1.6 nM and > 3 μM respectively).

Prevents opening of nicotinic receptor-associated ion channels and blocks neuromuscular transmission. Additionally acts as an imaging tool for fluorophore- labeling studies.

Solubility & Handling

Solubility overview

Soluble in water

Storage instructions

-20°C (desiccate)

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG

Molecular Weight

7984

Molecular Formula

C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

CAS Number

11032-79-4

PubChem identifier

90488742

SMILES

[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC2=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C2=O)C(C)C)[C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC2=CNC=N2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC2=CNC=N2)NC1=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)O

Source

Bungarus multicinctus

InChiKey

NTCJKZSYQTZRQE-CSMGIIAWSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for α-Bungarotoxin

References are publications that support the biological activity of the product

Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.
Hannan et al (2015) Neuropharmacology 93 : 28-40
Read more (PubMedID: 25634239)
Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.
Sine et al (2013) Biochem J 454(2) : 311-21
Read more (PubMedID: 23802200)
Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels.
Zhang et al (1994) Neuron 12(1) : 167-77
Read more (PubMedID: 7507338)
Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides.
Marinou et al (12614199) Biochem J 372 : 543-54
Read more (PubMedID: 12614199)

α7 subtype selective nAChR antagonist

Order: HB2038
Pack	Price	Qty
1mg	$206

α-Bungarotoxin

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for α-Bungarotoxin

Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.

Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels.

Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides.

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α-Bungarotoxin

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for α-Bungarotoxin

Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.

Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels.

Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides.

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Tell us about your publication!

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