It (AM251) works - bang for your buck! Works as described! Great technical support.Verified customer, UC Denver
Another quality product from Hello Bio - AM251 works as expected in our experiments and at a good price as well. We always order with confidence from Hello Bio, and are often surprised at how quickly we receive our products.Verified customer, University of South Carolina
AM251 is a potent and selective prototypic cannabinoid 1 receptor (CB1) antagonist / inverse agonist (IC50 = 8 nM and Ki = 7.49 nM).
AM251 shows ~306-fold selectivity over CB2 receptors. Structural analog of SR141716A.
Also acts as a potent GPR55 orphan receptor agonist (EC50 = 39 nM) and shows activity at the µ-opioid receptor (MOR) (Ki = 251 nM). Additionally, directly potentiates GABAA receptors.
AM251 attenuates responses to established cannabinoid receptor agonists in vitro or in vivo.
Blocks heterosynaptic long term depression (LTD).
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100 mM) and in ethanol (25 mM)
Handling
This compound is light sensitive; we therefore recommend protecting the solid material and solutions from exposure to light.
Ongoing solubility of AM251 in aqueous solutions can be unpredictable and the compound can precipitate out of solution.
We therefore recommend:
If possible, make up solutions and use immediately. Do not store solutions.
When creating your stock solutions, ensure the compound is fully dissolved in DMSO (use heat to achieve this if necessary).
Heat DMSO stock solution prior to addition to ACSF
Heat your ACSF solution to ~42°C before addition of AM251.
Mix the compound with ACSF immediately before use
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![AM 251 [183232-66-8] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb2776.png "AM 251 [183232-66-8]")
Understanding purity and quality - a guide for life scientists
