Selective and competitive carrier-mediated anandamide transport inhibitor (IC50 = 1 µM). Activates vanilloid receptors. Shows vasodilator, neuroprotective and anxiolytic actions mediated by 5-HT1A receptors.
Solubility & Handling
Solubility overview
Soluble in ethanol (50mM) or DMSO (50mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.
Braida D et al (2007) Eur J Pharmacol 555(2-3) : 156-63.
Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.
Zani A et al (2007) Br J Pharmacol 152(8) : 1301-11.
![AM 404 [183718-77-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1174.png "AM 404 [183718-77-6]")
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