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Images AM 404 product vial image | Hello Bio
AM 404 product vial image | Hello Bio Biological Data Biological description Selective and competitive carrier-mediated anandamide transport inhibitor (IC50 = 1 µM). Activates vanilloid receptors. Shows vasodilator, neuroprotective and anxiolytic actions mediated by 5-HT1A receptors.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -(4-Hydroxyphenyl)-5Z ,8Z ,11Z ,14Z -eicosatetraenamide
Chemical structure
Molecular Formula C26 H37 NO2
PubChem identifier 6604822
SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC1=CC=C(O)C=C1
InChiKey IJBZOOZRAXHERC-DOFZRALJSA-N
References for AM 404 References are publications that support the biological activity of the product
5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. Braida D et al (2007) Eur J Pharmacol 555(2-3) : 156-63. Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors. Zani A et al (2007) Br J Pharmacol 152(8) : 1301-11. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. Giuffrida A et al (2001) J Pharmacol Exp Ther 298(1) : 7-14. The anandamide transport inhibitor AM404 activates vanilloid receptors. Zygmunt PM et al (2000) Eur J Pharmacol 396(1) : 39-42.
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Selective, competitive carrier-mediated anandamide transport inhibitor