Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Ro 25-6981 maleate (HB0554)
Description:Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Purity:>98%
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Ro 32-0432 hydrochloride (HB4820)
Description:Potent, selective PKC inhibitor. GRK inhibitor.
Purity:>98%
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Ro 61-8048 (HB0556)
Description:Potent, competitive kynurenine 3-hydroxylase inhibitor
Purity:>99%
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(R)-(-)-Rolipram (HB2898)
Description:Potent, selective PDE4 inhibitor. Enantiomer of Rolipram.
Purity:>98%
