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Biological Data

Biological description Potent and selective protein kinase C inhibitor (IC50 values are 21, 9, 28, 31, 37 and 108 nM for PKC, PKC-α, PKC-β1, PKC-β2, PKC-γ and PKC-ε respectively). Displays 10 -and 4- fold selectivity for PKC-α and PKC-β1 over PKC-ε respectively. Also a G protein-coupled receptor kinase 5 inhibitor. Cell permeable. Displays anti-inflammatory properties.

Solubility & Handling

Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Bisindolylmaleimide XI hydrochloride
Molecular Weight 489.01
Molecular Formula C28H28N4O2 HCl
CAS Number 151342-35-7
PubChem identifier 11605551
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl

References for Ro-32-0432

References are publications that support the biological activity of the product
  • Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.

    Singh TG et al (2013) Naunyn Schmiedebergs Arch Pharmacol 386(3) : 197-204.
  • Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

    Birchall AM et al (1994) J Pharmacol Exp Ther 268(2) : 922-9.
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.