Product overview

Name Ro-32-0432
Description Potent, selective PKC inhibitor
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Biological Data

Biological description Potent and selective protein kinase C inhibitor (IC50 values are 21, 9, 28, 31, 37 and 108 nM for PKC, PKC-α, PKC-β1, PKC-β2, PKC-γ and PKC-ε respectively). Displays 10 -and 4- fold selectivity for PKC-α and PKC-β1 over PKC-ε respectively. Also a G protein-coupled receptor kinase 5 inhibitor. Cell permeable. Displays anti-inflammatory properties.

Solubility & Handling

Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Bisindolylmaleimide XI hydrochloride
Molecular Weight 489.01
Molecular Formula C28H28N4O2 HCl
CAS Number 151342-35-7
PubChem identifier 11605551
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl

References for Ro-32-0432

References are publications that support the biological activity of the product
  • Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.

    Singh TG et al (2013) Naunyn Schmiedebergs Arch Pharmacol 386(3) : 197-204.
  • Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

    Birchall AM et al (1994) J Pharmacol Exp Ther 268(2) : 922-9.
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.

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