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Ro 61-8048

(HB0556)
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Product overview

Name Ro 61-8048
Purity >99%
Description Potent, competitive kynurenine 3-hydroxylase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Blocks the effects of cannabinoid CB1 agonists. Displays antidystonic, neuroprotective and anticonvulsive properties. Blood brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (10mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >99%
Chemical name 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
Molecular Weight 421.45
Chemical structure Ro 61-8048 [199666-03-0] Chemical Structure
Molecular Formula C17H15N3O6S2
CAS Number 199666-03-0
PubChem identifier 5282337
SMILES O=S(NC1=NC(C2=CC=CC([N+]([O-])=O)=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O
InChiKey NDPBMCKQJOZAQX-UHFFFAOYSA-N

References for Ro 61-8048

References are publications that support the biological activity of the product

  • Kynurenines in the mammalian brain: when physiology meets pathology.

    Schwarcz R et al (2012) Nat Rev Neurosci 13(7) : 465-77.
    Read more (PubMedID: 22678511)

  • The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.

    Richter A et al (2003) Eur J Pharmacol 478(1) : 47-52.
    Read more (PubMedID: 14555184)

  • Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

    Röver S et al (1997) J Med Chem 40(26) : 4378-85.
    Read more (PubMedID: 9435907)

3 Item(s)

Related Products
Grouped product items
Order: HB0556
Pack PriceQty
50mg
$719
Potent, competitive kynurenine 3-hydroxylase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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