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Biological Data
| Biological description | Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Blocks the effects of cannabinoid CB1 agonists. Displays antidystonic, neuroprotective and anticonvulsive properties. Blood brain barrier permeable. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide |
| Chemical structure | ![Ro 61-8048 [199666-03-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Ro 61-8048 [199666-03-0]") |
| Molecular Formula | C17H15N3O6S2 |
| PubChem identifier | 5282337 |
| SMILES | O=S(NC1=NC(C2=CC=CC([N+]([O-])=O)=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O |
| InChiKey | NDPBMCKQJOZAQX-UHFFFAOYSA-N |
References for Ro 61-8048
References are publications that support the biological activity of the product
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Kynurenines in the mammalian brain: when physiology meets pathology.
Schwarcz R et al (2012) Nat Rev Neurosci 13(7) : 465-77. -
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Richter A et al (2003) Eur J Pharmacol 478(1) : 47-52. -
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
Röver S et al (1997) J Med Chem 40(26) : 4378-85.
Potent, competitive kynurenine 3-hydroxylase inhibitor
![Ro 61-8048 [199666-03-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0556.png "Ro 61-8048 [199666-03-0]")
Understanding purity and quality - a guide for life scientists
