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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
Pluripotin (HB2223)
Description:Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal.
Purity:>98%
PluriSln 1 (HB3573)
Description:SCD1 inhibitor. Selectively eliminates undifferentiated hPSCs from culture.
Purity:>99%
PLX4720 (HB4030)
Description:Potent and selective cell permeable B-Raf and C-Raf inhibitor
Purity:>99%
PNU 37883 hydrochloride (HB1105)
Description:Selective vascular KATP channel antagonist
Purity:>99%