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Images PKA inhibitor fragment (6-22) amide product vial image | Hello Bio
PKA inhibitor fragment (6-22) amide product vial image | Hello Bio Biological Data Biological description Potent protein kinase A (PKA) inhibitor (Ki = 1.6 nM). Decreases long-term potentiation (LTP) at hippocampal synapses. Reverses morphine tolerance.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in acetonitrile
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Molecular Formula C80 H130 N28 O24
PubChem identifier 16155227
SMILES [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
InChiKey VAKHFAFLRUNHLQ-PEBJKXEYSA-N
References for PKA inhibitor fragment (6-22) amide References are publications that support the biological activity of the product
Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Dalton GD et al (2005) Neuropharmacology 48(5) : 648-57. Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. Otmakhova NA et al (2000) J Neurosci 20(12) : 4446-51. Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase. Glass DB et al (1989) J Biol Chem 264(24) : 14579-84.
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