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PKA inhibitor fragment (6-22) amide

(HB0508)
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Product overview

Name PKA inhibitor fragment (6-22) amide
Alternative names Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Description Potent PKA inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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PKA inhibitor fragment (6-22) amide product vial image | Hello Bio
PKA inhibitor fragment (6-22) amide product vial image | Hello Bio

PKA inhibitor fragment (6-22) amide product vial image | Hello Bio

PKA inhibitor fragment (6-22) amide product vial image | Hello Bio

Biological Data

Biological description Potent protein kinase A (PKA) inhibitor (Ki = 1.6 nM). Decreases long-term potentiation (LTP) at hippocampal synapses. Reverses morphine tolerance.

Solubility & Handling

Solubility overview Soluble in acetonitrile
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Molecular Weight 1868.08
Molecular Formula C80H130N28O24
CAS Number 121932-06-7
PubChem identifier 16155227
SMILES [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
InChiKey VAKHFAFLRUNHLQ-PEBJKXEYSA-N

References for PKA inhibitor fragment (6-22) amide

References are publications that support the biological activity of the product

  • Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

    Dalton GD et al (2005) Neuropharmacology 48(5) : 648-57.
    Read more (PubMedID: 15814100)

  • Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.

    Otmakhova NA et al (2000) J Neurosci 20(12) : 4446-51.
    Read more (PubMedID: 10844013)

  • Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

    Glass DB et al (1989) J Biol Chem 264(24) : 14579-84.
    Read more (PubMedID: 2760075)

3 Item(s)

Grouped product items
Order: HB0508
Pack PriceQty
500μg
$110
1mg
$155
Potent PKA inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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