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Biological Data
| Biological description | Potent and selective protein kinase A (PKA) inhibitor (Ki = 2.8 nM). |
Solubility & Handling
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid |
| Molecular Formula | C18H24N4O3S.2HCl |
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)O)C(C)O)[C@@H](C)CC)C(C)O)C(=O)N[C@@H](Cc3[nH]cnc3)C(=O)N[C@@H](CC(O)=O)C(O)=O |
References for PKA Inhibitor IV
References are publications that support the biological activity of the product
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Sargaquinoic acid promotes neurite outgrowth via protein kinase A and MAP kinases-mediated signaling pathways in PC12D cells.
Kamei Y et al (2003) Int J Dev Neurosci 21(5) : 255-62. -
Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat.
Boylan JM et al (2001) J Biol Chem 276(48) : 44457-63.
Potent, selective PKA inhibitor
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