Broad spectrum protein kinase inhibitor. Inhibits PKC (isoforms α, β and γ), Syk, FLK-1, PKA, c-kit, Akt, FLT3, VEGFR1, VEGFR2, EGFR and c-src. Also selectively blocks TNF-α production. Displays antitumor, antiproliferative and pro-apoptotic properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (15mg/ml) or MDC (10mg/ml)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Tenzer A et al (2001) Cancer Res 61(22) : 8203-10.
![PKC-412 [120685-11-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0521.png "PKC-412 [120685-11-2]")
Understanding purity and quality - a guide for life scientists