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Biological Data Biological description Broad spectrum protein kinase inhibitor. Inhibits PKC (isoforms α, β and γ), Syk, FLK-1, PKA, c-kit, Akt, FLT3, VEGFR1, VEGFR2, EGFR and c-src. Also selectively blocks TNF-α production. Displays antitumor, antiproliferative and pro-apoptotic properties.
Solubility & Handling Solubility overview Soluble in DMSO (15mg/ml) or MDC (10mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name Midostaurin; 4'-N-benzoylstaurosporine
Chemical structure
Molecular Formula C35 H30 N4 O4
SMILES CO[C@]1(C)[C@@H]([C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35)N(C)C(=O)c9ccccc9
References for PKC-412 References are publications that support the biological activity of the product
Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production. Si MS et al (2005) Int Immunopharmacol 5(7-8) : 1141-9. PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Nakazono-Kusaba A et al (2004) Eur J Pharmacol 497(2) : 155-60. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Tenzer A et al (2001) Cancer Res 61(22) : 8203-10. PKC412--a protein kinase inhibitor with a broad therapeutic potential. Fabbro D et al (2000) Anticancer Drug Des 15(1) : 17-28.
Broad spectrum protein kinase inhibitor
![PKC-412 [120685-11-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0521.png "PKC-412 [120685-11-2]")
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