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Biological Data
| Biological description | Selective vascular KATP channel antagonist (IC50 values are 15 and 6 µM for SUR2B/ Kir6.2 and SUR2B/ Kir6.1 channels respectively). Also Kir6.2δ26 channel inhibitor (IC50 = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal kATP channels. Displays diuretic properties. |
Solubility & Handling
| Storage instructions | room temperature (desiccate) |
| Solubility overview | Soluble in DMSO (25mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride |
| Chemical structure | ![PNU 37883 hydrochloride [57568-80-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "PNU 37883 hydrochloride [57568-80-6]") |
| Molecular Formula | C21H35N3O.HCl |
| SMILES | C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl |
| InChiKey | FZALCKUJYZCDOX-UHFFFAOYSA-N |
References for PNU 37883 hydrochloride
References are publications that support the biological activity of the product
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Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.
Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32. -
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73. -
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.
Selective vascular KATP channel antagonist
![PNU 37883 hydrochloride [57568-80-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1105.png "PNU 37883 hydrochloride [57568-80-6]")
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