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PNU 37883 hydrochloride

(HB1105)
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Product overview

Name PNU 37883 hydrochloride
Purity >99%
Description Selective vascular KATP channel antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective vascular KATP channel antagonist (IC50 values are 15 and 6 µM for SUR2B/ Kir6.2 and SUR2B/ Kir6.1 channels respectively). Also Kir6.2δ26 channel inhibitor (IC50 = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal kATP channels. Displays diuretic properties.

Solubility & Handling

Solubility overview Soluble in DMSO (25mM) or ethanol (100mM)
Storage instructions room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Molecular Weight 381.98
Chemical structure PNU 37883 hydrochloride [57568-80-6] Chemical Structure
Molecular Formula C21H35N3O.HCl
CAS Number 57568-80-6
PubChem identifier 64392
SMILES C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl
InChiKey FZALCKUJYZCDOX-UHFFFAOYSA-N

References for PNU 37883 hydrochloride

References are publications that support the biological activity of the product

  • Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.

    Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.
    Read more (PubMedID: 16939631)

  • Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.

    Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.
    Read more (PubMedID: 14757705)

  • Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.

    Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.
    Read more (PubMedID: 12746230)

3 Item(s)

Grouped product items
Order: HB1105
Pack PriceQty
10mg
$148
50mg
$588
Selective vascular KATP channel antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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