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Images PK 11195 product vial image | Hello Bio
PK 11195 product vial image | Hello Bio Biological Data Biological description Peripheral benzodiazepine receptor ligand. Inhibits the constitutive androstane receptor (CAR; NR1I3). Shows actions against Alzheimer's disease. Shows anti-convulsive actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1-(2-Chlorophenyl)-N -methyl-N -(1-methylpropyl)-3-isoquinolinecarboxamide
Chemical structure
Molecular Formula C21 H21 ClN2 O
SMILES CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1
InChiKey RAVIZVQZGXBOQO-UHFFFAOYSA-N
References for PK 11195 References are publications that support the biological activity of the product
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. Barron AM et al (2013) J Neurosci 33(20) : 8891-7. The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Li L et al (2008) Mol Pharmacol 74(2) : 443-53. PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. Veenman L et al (2002) J Neurochem 80(5) : 917-27.
Peripheral benzodiazepine receptor ligand
![PK 11195 [85532-75-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0922.png "PK 11195 [85532-75-8]")
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