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PK 11195

(HB0922)
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Technical documents: SDS Datasheet
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Product overview

Name PK 11195
Purity >98%
Description Peripheral benzodiazepine receptor ligand
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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PK 11195 product vial image | Hello Bio
PK 11195 product vial image | Hello Bio

PK 11195 product vial image | Hello Bio

PK 11195 product vial image | Hello Bio

Biological Data

Biological description Peripheral benzodiazepine receptor ligand. Inhibits the constitutive androstane receptor (CAR; NR1I3). Shows actions against Alzheimer's disease. Shows anti-convulsive actions.

Solubility & Handling

Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Molecular Weight 352.86
Chemical structure PK 11195 [85532-75-8] Chemical Structure
Molecular Formula C21H21ClN2O
CAS Number 85532-75-8
PubChem identifier 1345
SMILES CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1
InChiKey RAVIZVQZGXBOQO-UHFFFAOYSA-N

References for PK 11195

References are publications that support the biological activity of the product

  • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.

    Barron AM et al (2013) J Neurosci 33(20) : 8891-7.
    Read more (PubMedID: 23678130)

  • The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

    Li L et al (2008) Mol Pharmacol 74(2) : 443-53.
    Read more (PubMedID: 18492798)

  • PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.

    Veenman L et al (2002) J Neurochem 80(5) : 917-27.
    Read more (PubMedID: 11948256)

3 Item(s)

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Grouped product items
Order: HB0922
Pack PriceQty
50mg
$338
Peripheral benzodiazepine receptor ligand
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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