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ZM 447439

(HB1444)
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Product overview

Name ZM 447439
Purity >99%
Description Potent, selective, ATP-competitive Aurora kinase B inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent, selective and ATP-competitive Aurora kinase B inhibitor (IC50 values are 50, 250 and 1000 nM for Aurora kinase B, C and A respectively). Inhibits mitotic chromosome alignment, mitotic segregation and cytokinesis. Shows anti-proliferative and anti-cancer actions.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N-[4-[[6-Methoxy-7-[3-(4-morpholiny l)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Molecular Weight 513.59
Chemical structure ZM 447439 [331771-20-1] Chemical Structure
Molecular Formula C29H31N5O4
CAS Number 331771-20-1
PubChem identifier 9914412
SMILES COC1=CC2=C(NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3)N=CN=C2C=C1OCCCN1CCOCC1
InChiKey OGNYUTNQZVRGMN-UHFFFAOYSA-N

References for ZM 447439

References are publications that support the biological activity of the product

  • ZM447439, the Aurora kinase B inhibitor, suppresses the growth of cervical cancer SiHa cells and enhances the chemosensitivity to cisplatin.

    Zhang L et al (2011) J Obstet Gynaecol Res 37(6) : 591-600.
    Read more (PubMedID: 21159048)

  • Validating Aurora B as an anti-cancer drug target.

    Girdler F et al (2006) J Cell Sci 119(Pt 17) : 3664-75.
    Read more (PubMedID: 16912073)

  • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

    Ditchfield C et al (2003) J Cell Biol 161(2) : 267-80.
    Read more (PubMedID: 12719470)

3 Item(s)

Grouped product items
Order: HB1444
Pack PriceQty
10mg
$244
50mg
$989
Potent, selective, ATP-competitive Aurora kinase B inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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