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ZIP

(HB0669)
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Technical documents: SDS CoA Datasheet

Product overview

Name ZIP
Biological description

Zeta inhibitory peptide (ZIP) is a cell permeable protein kinase MZeta (PKMζ) inhibitor. Selectively prevents long term potentiation (LTP) maintenance in vitro and disrupts maintenance of hippocampal LTP in vivo. ZIP interferes with the maintenance of acquired memories and has disruptive effects on memory (e.g. spatial / recognition memory and aversive and appetitive memories) via an unknown mechanism of action.

Alternative names z-Pseudosubstrate inhibitory peptide
Purity >95%
Description

PKMζ inhibitor. Interferes with the maintenance of acquired memories.

Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Images

ZIP product vial image | Hello Bio
ZIP product vial image | Hello Bio

ZIP product vial image | Hello Bio

ZIP product vial image | Hello Bio

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview

Soluble in water (1 mg/ml)

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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x
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Dilution

x
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Chemical Data

Purity >95%
Chemical name

Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Molecular Weight 1928.4
Molecular Formula C90H154N30O17
CAS Number 863987-12-6
PubChem identifier 16156119
SMILES [H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC
InChiKey CRKARHQCXWSUMV-HOHDCHNJSA-N

References for ZIP

References are publications that support the biological activity of the product

  • Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.

    Wu-Zhang AX et al (2012) J Biol Chem 287(16) : 12879-85.
    Read more (PubMedID: 22378786)

  • Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation.

    Serrano P et al (2005) J Neurosci 25(8) : 1979-84.
    Read more (PubMedID: 15728837)

  • Protein kinase Mzeta is necessary and sufficient for LTP maintenance.

    Ling DS et al (2002) Nat Neurosci 5(4) : 295-6.
    Read more (PubMedID: 11914719)

3 Item(s)

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Order: HB0669
Pack PriceQty
1mg
$186

PKMζ inhibitor. Interferes with the maintenance of acquired memories.

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