Product overview

Name Zoledronic acid
Description Highly potent bisphosphonate, shows variety of biological actions
Alternative names Zometa
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Biological Data

Biological description

Highly potent bisphosphonate, shows variety of biological actions. Ras signaling inhibitor. Inhibits bone metastasis. Shows apoptotic effects and inhibits proliferation. Also reduces tumour burden and growth.

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Zoledronate
Molecular Weight 272.09
Chemical structure Zoledronic acid  [118072-93-8] Chemical Structure
Molecular Formula C5H10N2O7P2
CAS Number 118072-93-8
PubChem identifier 68740
SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChiKey XRASPMIURGNCCH-UHFFFAOYSA-N

References for Zoledronic acid

References are publications that support the biological activity of the product
  • Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells.

    Rizzo A et al (2014) Int Immunopharmacol 22(1) : 66-72.
  • Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.

    Rietkötter E et al (2013) Oncotarget 4(9) : 1449-60.
  • Antineoplastic activity of zoledronic acid and denosumab.

    Zwolak P et al (2013) Anticancer Res 33(8) : 2981-8.