Product overview
Name | Zoledronic acid |
Description | Highly potent bisphosphonate, shows variety of biological actions |
Alternative names | Zometa |
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Biological Data
Biological description | Highly potent bisphosphonate, shows variety of biological actions. Ras signaling inhibitor. Inhibits bone metastasis. Shows apoptotic effects and inhibits proliferation. Also reduces tumour burden and growth. |
Solubility & Handling
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | Zoledronate |
Molecular Weight | 272.09 |
Chemical structure | |
Molecular Formula | C5H10N2O7P2 |
CAS Number | 118072-93-8 |
PubChem identifier | 68740 |
SMILES | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O |
InChiKey | XRASPMIURGNCCH-UHFFFAOYSA-N |
References for Zoledronic acid
References are publications that support the biological activity of the product
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Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells.
Rizzo A et al (2014) Int Immunopharmacol 22(1) : 66-72. -
Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.
Rietkötter E et al (2013) Oncotarget 4(9) : 1449-60. -
Antineoplastic activity of zoledronic acid and denosumab.
Zwolak P et al (2013) Anticancer Res 33(8) : 2981-8.