Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Technical documents: Datasheet

Product overview

Name Z-Leu-Leu-Leu-B(OH)2 (MG-262)
Alternative names MG-262 | ZL3B | Z-LLL-B(OH)2
Purity >95%
Description Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
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Biological Data

Biological description Highly potent, selective, reversible cell permeable proteasome inhibitor. More potent than MG-132. Inhibits chymotrypsin- and caspase-like peptidase activity of the proteasome. Also shows calpain and cathepsin inhibitor. Activates autophagy and induces apoptosis.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name Z-Leu-Leu-Leu-B(OH)2
Molecular Weight 491.4
Molecular Formula C25H42BN3O6
CAS Number 179324-22-2
Appearance Solid lyophilized powder

References for Z-Leu-Leu-Leu-B(OH)2 (MG-262)

References are publications that support the biological activity of the product
  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42
  • Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.

    Pujols L et al (2012) J Pharmacol Exp Ther 343(1) : 184-97
  • Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

    Reynolds JM et al (2007) BMC Clin Pharmacol. 23 : 7-13
  • Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

    Frase H et al (2006) Biochemistry 45(27) : 8264-74

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