My Cart
My account
Menu
Main Menu

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

(HB4134)
Be the first to add a publication
Technical documents: Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name Z-Leu-Leu-Leu-B(OH)2 (MG-262)
Alternative names MG-262 | ZL3B | Z-LLL-B(OH)2
Purity >95%
Description Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
Write Your Own Review
You're reviewing:Z-Leu-Leu-Leu-B(OH)2 (MG-262)
Rate this item:

Biological Data

Biological description Highly potent, selective, reversible cell permeable proteasome inhibitor. More potent than MG-132. Inhibits chymotrypsin- and caspase-like peptidase activity of the proteasome. Also shows calpain and cathepsin inhibitor. Activates autophagy and induces apoptosis.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Chemical name Z-Leu-Leu-Leu-B(OH)2
Molecular Weight 491.4
Molecular Formula C25H42BN3O6
CAS Number 179324-22-2
InChiKey MWKOOGAFELWOCD-FKBYEOEOSA-N
Appearance Solid lyophilized powder

References for Z-Leu-Leu-Leu-B(OH)2 (MG-262)

References are publications that support the biological activity of the product

  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42
    Read more (PubMedID: 25859045)

  • Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.

    Pujols L et al (2012) J Pharmacol Exp Ther 343(1) : 184-97
    Read more (PubMedID: 22787116)

  • Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

    Reynolds JM et al (2007) BMC Clin Pharmacol. 23 : 7-13
    Read more (PubMedID: http://www.ncbi.nlm.nih.gov/pubm)

  • Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

    Frase H et al (2006) Biochemistry 45(27) : 8264-74
    Read more (PubMedID: 16819825)

4 Item(s)

Grouped product items
Order: HB4134
Pack PriceQty
200μg
$270
1mg
$1,342
Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

Pexidartinib (PLX3397)
HB8991

Potent CSF-1R inhibitor. Widely used microglia-depletion agent.