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Z-Leu-Leu-Leu-B(OH)2 (MG-262)

(HB4134)
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Product overview

Name Z-Leu-Leu-Leu-B(OH)2 (MG-262)
Alternative names MG-262 | ZL3B | Z-LLL-B(OH)2
Purity >95%
Description Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Highly potent, selective, reversible cell permeable proteasome inhibitor. More potent than MG-132. Inhibits chymotrypsin- and caspase-like peptidase activity of the proteasome. Also shows calpain and cathepsin inhibitor. Activates autophagy and induces apoptosis.

Solubility & Handling

Solubility overview Soluble in DMSO
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name Z-Leu-Leu-Leu-B(OH)2
Molecular Weight 491.4
Molecular Formula C25H42BN3O6
CAS Number 179324-22-2
InChiKey MWKOOGAFELWOCD-FKBYEOEOSA-N
Appearance Solid lyophilized powder

References for Z-Leu-Leu-Leu-B(OH)2 (MG-262)

References are publications that support the biological activity of the product

  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Das I et al (2015) Science 348(6231) : 239-42
    Read more (PubMedID: 25859045)

  • Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.

    Pujols L et al (2012) J Pharmacol Exp Ther 343(1) : 184-97
    Read more (PubMedID: 22787116)

  • Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.

    Reynolds JM et al (2007) BMC Clin Pharmacol. 23 : 7-13
    Read more (PubMedID: http://www.ncbi.nlm.nih.gov/pubm)

  • Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

    Frase H et al (2006) Biochemistry 45(27) : 8264-74
    Read more (PubMedID: 16819825)

4 Item(s)

Grouped product items
Order: HB4134
Pack PriceQty
200μg
$278
1mg
$1,382
Highly potent, selective, cell permeable proteasome inhibitor. More potent than MG-132.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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