Clozapine dihydrochloride (water soluble)

(HB6129)
Technical documents: SDS CoA Datasheet

Product overview

Name Clozapine dihydrochloride (water soluble)
Description Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.
Purity >98%
Customer comments

I am very pleased with this product: Clozapine dihydrochloride (clozapine-2HCl). It dissolves in saline (0.9% NaCl) well and produces the expected biological effects when injected into the mouse. Its water solubility is highly useful because the free base clozapine does not dissolve in water/saline, limiting its use in intact animals. Verified customer, UTHSC

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Biological Data

Biological description

Water soluble clozapine is a prototypic, atypical antipsychotic which binds to both serotonin and dopamine receptors (Ki values are 35, 83 and 22, 250 and 141 nM at D2, D3 and D4, D5, D1 and 12.6 and 13.2 nM at 5-HT2A and 5-HT2C receptors respectively) and also shows activity at other receptors.


Clozapine shows high BBB permeability and is active in vivo. It shows antipsychotic, antidepression and anxiolytic activites.


Recently, clozapine (which CNO rapidly converts to) has been indicated to show high DREADD (hM3Dq and hM4Di) affinity and potency. Subthreshold clozapine injections are indicated to induce preferential DREADD-mediated behaviors.


Clozapine also available

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (100 mM). Always store solutions at -20°C.
Handling

Storage of solid

  • Store at -20°C.
  • Please note that the compound is a hydroscopic solid and contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.

Storage of solutions

  • Make up solutions and use immediately.
  • If storage of solutions is required, you should aliquot out the solution into tightly sealed vials and store at -20°C and store these for up to one month.
  • Allow the product to equilibrate to RT for at least one hour before opening and using.

  • Storage of solutions at room temperature

  • We recommend only keeping solutions at room temperature (25°C) for a few days as our studies have shown that after 96 hours the purity of the compound in solution drops to ~95% and will continue to drop over time.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Molecular Weight 399.75
Chemical structure Clozapine hydrochloride [54241-01-9] Chemical Structure
Molecular Formula C18H19N4 · 2HCl
CAS Number 54241-01-9
PubChem identifier 148669
SMILES CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl.Cl
Source Synthetic
InChi InChI=1S/C18H19ClN4.ClH/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18;/h2-7,12,21H,8-11H2,1H3;1H
InChiKey VFDNENKXDGAOSN-UHFFFAOYSA-N
Appearance Orange solid

References for Clozapine dihydrochloride (water soluble)

References are publications that support the biological activity of the product
  • DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.

    Goutaudier et al (2019) eNeuro 6 : (5)
  • Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.

    Gomez et al (2017) Science 357(6350) : 503-507
  • Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

    Sunahara RK et alStrange PG (2001) Pharmacol Rev 53(1) : 119-33.
  • Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs.

    Kuoppamã?ki M et al (1995) Neuropsychopharmacology 13(2) : 139-50.
  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.
Publications
These publications cite the use of Clozapine dihydrochloride (water soluble) purchased from Hello Bio:
  • The Gut-Brain Axis Mediates Sugar Preference

    Hwei-Ee Tan (2020) Nature 580(7804) : 511-516
    PubMedID: 32322067

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