Clozapine

(HB1607)
Technical documents: SDS CoA Datasheet

Product overview

Name Clozapine
Description Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors
Alternative names CLZ-ChemoNM
Purity >99%
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Biological Data

Biological description

Clozapine is a prototypic, atypical antipsychotic which binds to both serotonin and dopamine receptors (Ki values are 35, 83 and 22, 250 and 141 nM at D2, D3 and D4, D5, D1 and 12.6 and 13.2 nM at 5-HT2A and 5-HT2C receptors respectively) and also shows activity at other receptors.


Clozapine shows high BBB permeability and is active in vivo. It shows antisychotic, antidepression and anxiolytic activites.


Recently, clozapine (which CNO rapidly converts to) has been indicated to show high DREADD (hM3Dq and hM4Di) affinity and potency. Subthreshold clozapine injections are indicated to induce preferential DREADD-mediated behaviors.


Water soluble version of clozapine also available

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM) and in ethanol (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Molecular Weight 326.83
Chemical structure Clozapine  [5786-21-0] Chemical Structure
Molecular Formula C18H19ClN4
CAS Number 5786-21-0
PubChem identifier 2818
SMILES CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
InChi InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
InChiKey ZUXABONWMNSFBN-UHFFFAOYSA-N
MDL number MFCD00153785
Appearance Yellow solid

References for Clozapine

References are publications that support the biological activity of the product
  • DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.

    Goutaudier et al (2019) eNeuro 6 : (5)
  • Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.

    Gomez et al (2017) Science 357(6350) : 503-507
  • Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

    Strange PG (2001) Pharmacol Rev 53(1) : 119-33.
  • Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs.

    Kuoppamã?ki M et al (1995) Neuropsychopharmacology 13(2) : 139-50.
  • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

    Sunahara RK et al (1991) Nature 350(6319) : 614-9.
Publications
These publications cite the use of Clozapine purchased from Hello Bio:
  • Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales

    N Shadlen et al (2021) bioRxiv https://doi.org/10.1101/2021.09.10.459856 : doi
  • Dorsal Raphe Projections to the Mesocorticolimbic System Modulate Core Aspects of Appetitive Learning and Responding

    Tapp et al (2021) Miami University : Thesis

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