Product overview
| Name | Clozapine |
| Description | Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors |
| Alternative names | CLZ-ChemoNM |
| Purity | >99% |
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Biological Data
| Biological description | Clozapine is a prototypic, atypical antipsychotic which binds to both serotonin and dopamine receptors (Ki values are 35, 83 and 22, 250 and 141 nM at D2, D3 and D4, D5, D1 and 12.6 and 13.2 nM at 5-HT2A and 5-HT2C receptors respectively) and also shows activity at other receptors.
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Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100 mM) and in ethanol (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Molecular Weight | 326.83 |
| Chemical structure | ![Clozapine [5786-21-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1607.png "Clozapine [5786-21-0]") |
| Molecular Formula | C18H19ClN4 |
| CAS Number | 5786-21-0 |
| PubChem identifier | 2818 |
| SMILES | CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl |
| InChi | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 |
| InChiKey | ZUXABONWMNSFBN-UHFFFAOYSA-N |
| MDL number | MFCD00153785 |
| Appearance | Yellow solid |
References for Clozapine
References are publications that support the biological activity of the product
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DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.
Goutaudier et al (2019) eNeuro 6 : (5) -
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Gomez et al (2017) Science 357(6350) : 503-507 -
Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.
Strange PG (2001) Pharmacol Rev 53(1) : 119-33. -
Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs.
Kuoppamã?ki M et al (1995) Neuropsychopharmacology 13(2) : 139-50. -
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Sunahara RK et al (1991) Nature 350(6319) : 614-9.
Publications
These publications cite the use of Clozapine purchased from Hello Bio:
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Chemogenetic dissection of prefrontal signalling underlying attention and impulsivity
van der Veen et al (2022) Universität Ulm : Thesis -
Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales
N Shadlen et al (2021) bioRxiv https://doi.org/10.1101/2021.09.10.459856 : doi -
Dorsal Raphe Projections to the Mesocorticolimbic System Modulate Core Aspects of Appetitive Learning and Responding
Tapp et al (2021) Miami University : Thesis
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