Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Jasplakinolide (HB3946)

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    Description:

    Cell permeable, non-fluorescent F-actin probe. Induces actin polymerization and stabilization.

    Purity:

    >98%

    Pack:
    50μg
    Price:
    $223
    Qty:
    Pack:
    100μg
    Price:
    $409
    Qty:
  2. JC-1 (HB0791)

    Description:

    Mitochondrial membrane potential indicator/dye. Widely used in apoptosis studies.

    Purity:

    >95%

    Pack:
    5mg
    Price:
    $447
    Qty:
  3. Jedi2 (HB8049)

    Description:

    Piezo1 channel activator

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $108
    Qty:
    Pack:
    50mg
    Price:
    $450
    Qty:
  4. Pack:
    10mg
    Price:
    $135
    Qty:
  5. Description:

    Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $66
    Qty:
    Pack:
    5mg
    Price:
    $312
    Qty:
  6. Description:

    Yellow dye supplied as a free acid. Suitable for dSTORM, STED, confocal microscopy, live cell imaging and flow cytometry.

    Pack:
    5mg
    Price:
    $353
    Qty:
  7. Description:

    Yellow dye for coupling to NHS groups. Suitable for dSTORM, STED, confocal microscopy, live cell imaging and flow cytometry.

    Pack:
    100μg
    Price:
    Qty:
    Pack:
    3 x 100μg
    Price:
    $206
    Qty:
    Pack:
    2mg
    Price:
    $311
    Qty:
  8. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Freebase.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $102
    Qty:
    Pack:
    10mg
    Price:
    $199
    Qty:
    Pack:
    25mg
    Price:
    $420
    Qty:
    Pack:
    100mg
    Price:
    $1,099
    Qty:
  9. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Water soluble.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $102
    Qty:
    Pack:
    10mg
    Price:
    $199
    Qty:
    Pack:
    25mg
    Price:
    $420
    Qty:
    Pack:
    100mg
    Price:
    $1,548
    Qty:
  10. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Freebase.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $94
    Qty:
    Pack:
    10mg
    Price:
    $165
    Qty:
    Pack:
    25mg
    Price:
    $363
    Qty:
    Pack:
    50mg
    Price:
    $605
    Qty:
    Pack:
    100mg
    Price:
    $1,095
    Qty:
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