JF-NP-26 (Caged-Raseglurant)
Product overview
| Name | JF-NP-26 (Caged-Raseglurant) |
| Description | Novel, inactive photocaged derivative of raseglurant which can be uncaged with violet light. Shows light-dependent analgesic activity in vivo. |
| Purity | >98% |
Biological Data
| Biological description | JF-NP-26 (Caged-Raseglurant) is a novel, inactive photocaged derivative of raseglurant/ADX-10059 (the mGlu5 receptor negative allosteric modulator (NAM)).
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Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Handling | This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | (7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyidin-3-yl)carbamate |
| Molecular Weight | 513.57 |
| Chemical structure |  |
| Molecular Formula | C30H28FN3O4 |
| Source | Synthetic |
| InChiKey | XBUISHYVUXKBCO-UHFFFAOYSA-N |
| Appearance | Yellow solid |
References for JF-NP-26 (Caged-Raseglurant)
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.
Font et al (2017) ELife pii: e23545. : doi: 10.7554/eLife.23545.
Understanding purity and quality - a guide for life scientists
