|Description|| Mitochondrial membrane potential indicator/dye. Widely used in apoptosis studies. |
|Biological description|| |
Mitochondrial membrane potential indicator/dye which is widely used in apoptosis studies to monitor mitochondrial health.
It can be used as an indicator of mitochondrial membrane potential in various cell types including neurons and myocytes and also intact tissues and isolated mitochondria.
At low concentrations (due to low mitochondrial membrane potential), JC-1 is predominantly a monomer that yields green fluorescence with emission of 530±15 nm.
At high concentrations (due to high mitochondrial membrane potential), the dye aggregates yielding a red to orange colored emission (590±17.5 nm).
Depolarization is indicated by a decrease the aggregate fluorescent count and hyperpolarization is indicated by an increase.
Allows both qualitative visualization and quantitative detection.
Solubility & Handling
|Storage instructions|| -20°C |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
|Chemical name|| 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide |
|Chemical structure|| |
|Molecular Formula|| C25H27Cl4IN4 |
References for JC-1
References are publications that support the biological activity of the product
Functional live cell imaging of the pulmonary neuroepithelial body microenvironment.
De Proost I et al (2008) Am J Respir Cell Mol Biol 39(2) : 180-9.
Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria.
Liu T et al (2007) Mol Cancer Ther 6(6) : 1814-22.