Histone deacetylase (HDAC)
Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.
ITD 1 (HB3446)
Description:Selective TGF-β signaling inhibitor. Induces cardiomyocyte differentiation in ESCs.
Purity:>98%
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Ivermectin (IVM) (HB1958)
Description:α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.
Purity:>95%
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IWP 2 (HB0344)
Description:Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.
Purity:>98%
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IWP 4 (HB3066)
Description:Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.
Purity:>98%
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Janelia Fluor® 525, free acid (HB7173)
Description:Yellow dye supplied as a free acid. Suitable for super resolution microscopy (e.g. dSTORM), confocal microscopy and live cell imaging.
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Janelia Fluor® 525, SE (HB8455)
Description:Yellow dye for coupling to NHS groups. Suitable for super resolution microscopy (e.g. dSTORM), confocal microscopy and live cell imaging.
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Janelia Fluor® 549, Azide (HB7988)
Description:Yellow dye supplied as an azide for click chemistry. Suitable for dSTORM, STED, confocal microscopy, live cell imaging and flow cytometry.
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Janelia Fluor® 549, Tetrazine (HB7228)
Description:Yellow dye supplied with a tetrazine reactive handle for copper-free click chemistry. Suitable for dSTORM, STED, confocal microscopy and live cell imaging.
