Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Cyclosporin A (HB0220)

    Description:

    Potent calcineurin inhibitor. Inhibits MPTP opening.

    Purity:

    >99%

    Pack:
    100mg
    Price:
    $100
    Qty:
  2. Cyclosporin C (HB3859)

    Description:

    Calcineurin inhibitor. Immuosuppresant.

    Purity:

    >95%

    Pack:
    5mg
    Price:
    $304
    Qty:
  3. Cyclosporin D (HB3860)

    Description:

    Calcineurin inhibitor. Potent inhibitor of tumor promoting phorbol ester (TPA/PMA) effects.

    Purity:

    >97%

    Pack:
    5mg
    Price:
    $282
    Qty:
  4. Cytostatin (HB3864)

    Description:

    Potent, selective PP2A inhibitor

    Purity:

    >75%

    Pack:
    250μg
    Price:
    $357
    Qty:
  5. Pack:
    10mg
    Price:
    $215
    Qty:
    Pack:
    50mg
    Price:
    $836
    Qty:
  6. Pack:
    100mg
    Price:
    $151
    Qty:
    Pack:
    500mg
    Price:
    $609
    Qty:
  7. DAPT (HB3345)

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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $103
    Free trial
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    25mg
    Price:
    $436
    Qty:
    Pack:
    50mg
    Price:
    $733
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $114
    Qty:
  8. Description:

    RNA and DNA synthesis inhibitor. Antibiotic.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $118
    Qty:
    Pack:
    50mg
    Price:
    $246
    Qty:
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